解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::An improved method was developed for measuring malondialdehyde (MDA) as its thiobarbituric acid (TBA) complex. Samples were initially incubated with 1% potassium iodide and 0.1% butylated hydroxytoluene at 50 degrees C for 20 min, and then with 0.4% TBA at 60 degrees C for 60 min. The MDA-TBA complex formed was extrac...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537094
更新日期:1994-01-01 00:00:00
abstract::The ganglioside levels in atherosclerotic lesions of human aorta are considerably higher than those in unaffected areas of aorta, and atherosclerotic patients frequently have increased concentrations of serum gangliosides. The present review summarizes recent findings that suggest the possible involvement of aortic ga...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02537083
更新日期:1994-01-01 00:00:00
abstract::Lifibrol, a new hypocholesterolemic agent with activity in humans, was examined in normal rats for its short-term and long-term effects on lipid homeostasis. Cholesterol (Chol) synthesis inhibition by lifibrol was demonstrated in vitro in liver minces from normal rats by following [1-14C]acetate ([14C]Ac) and DL-[2-14...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537074
更新日期:1993-12-01 00:00:00
abstract::Previous studies from our laboratory have shown that retinitis pigmentosa (RP), a family of hereditary retinal degenerations, is often accompanied by abnormal levels of cholesterol or polyunsaturated fatty acids. The requirement of the retina for n-3 fatty acids is well known, and a defect in the supply of these lipid...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537120
更新日期:1993-11-01 00:00:00
abstract::We have previously reported that the relative content of 18:3 omega 3 in adipose triglyceride (TG) of women was reduced following major weight loss while on a very low calorie diet (VLCD). In an attempt to prevent this loss of 18:3 omega 3 reserves, we have tested two VLCD supplemented with varying amounts of 18:3 ome...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537119
更新日期:1993-11-01 00:00:00
abstract::Screening for resistance to fenpropimorph was undertaken in order to isolate yeast mutants affected in the regulation of the ergosterol pathway. Among the mutants isolated, one bearing the recessive fen1-1 mutation was characterized by a 1.5-fold increase in the ergosterol level and a general resistance to sterol bios...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537499
更新日期:1993-10-01 00:00:00
abstract::The phospholipid and the fatty chain compositions of diacyl, alkylacyl and alkenylacyl glycerophospholipids of the free-living nematode, Caenorhabditis elegans, were investigated. The phospholipids were comprised of 54.5% ethanolamine glycerophospholipid (EGP), 32.3% choline glycerophospholipid (CGP), 8.1% sphingomyel...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536239
更新日期:1993-09-01 00:00:00
abstract::The composition of the glycosphingolipids of the human gastrointestinal tract was studied. The major neutral glycosphingolipids were ceramide monohexosides (e.g., GalCer, GlcCer), LacCer, Gb3Cer, Gb4Cer and more polar ones with more than four sugars, whereas neither Gg3Cer nor Gg4Cer were present. The acidic glycosphi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535996
更新日期:1993-08-01 00:00:00
abstract::This study was designed to examine the incorporation of omega-3 (n-3) fatty acids into the immune tissues of pigs nursing fish oil-fed sows and to determine the effect of maternal dietary n-3 consumption on in vitro immune cell eicosanoid production. On day 107 of gestation, 12 sows were randomly allotted to a diet co...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535986
更新日期:1993-08-01 00:00:00
abstract::The uptake of lipid from the yolk by the yolk sac membrane of the chick embryo is accompanied by the rapid esterification of a large proportion of the yolk cholesterol. This could arise from enhanced acyl-CoA:cholesterol acyltransferase (ACAT) activity and/or inhibition of cholesteryl ester hydrolase (CEH) activity. T...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536056
更新日期:1993-07-01 00:00:00
abstract::In an attempt to clarify the mechanism of lipid accumulation inMortierella ramanniana var.angulispora, diacylglycerol acyltransferase (DGAT) in the membrane fraction from this fungus was characterized. The enzyme had an optimum pH of 7.0-7.5, and enzyme activity was blocked by SH-reagents. Metal ions were not essentia...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536050
更新日期:1993-07-01 00:00:00
abstract::We examined the effect of dietary alpha-linolenic acid (ALA) on the indices of lipid and coagulation status and on the fatty acid composition of serum and peripheral blood mononuclear cell (PBMNC) lipids in ten healthy men (age 21-37 yr) who consumed all their meals at the Western Human Nutrition Research Center for 1...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536085
更新日期:1993-06-01 00:00:00
abstract::The purpose of the present study was to investigate the physiological control of the main regulatory enzymes of cholesterol metabolism in isolated enterocytes obtained from chick duodenum, jejunum and ileum. Cholesterol feeding resulted in an inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and mevalonate 5-pyr...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536087
更新日期:1993-06-01 00:00:00
abstract::The effects of increasing concentrations of eicosapentaenoic acid (20:5n-3; EPA) and oleic acid (18:1n-9; OA) on esterification to triacylglycerols (TG) and phospholipids (PL), and the relationship to formation and secretion of the very low density lipoproteins (VLDL) were compared in the isolated perfused rat liver. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535940
更新日期:1993-05-01 00:00:00
abstract::This study was undertaken to investigate the total plasma fatty acid composition and the relationship between plasma triacylglycerol (TG) levels and liver delta 9 desaturase activity in mice fed n-3 and/or n-6 fatty acid or hydrogenated coconut oil (HCO) (maximum 25 mg/g) supplemented diets. Generally, plasma TG level...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536312
更新日期:1993-04-01 00:00:00
abstract::Intact washed human platelets aggregated in response to paf-acether (paf) and did not metabolize [3H]paf at concentrations up to 10 nM. However, when platelets were lysed by exposure to pH 9.5, resulting in 37.5 +/- 2.5% (mean +/- SD, n = 3) lactic dehydrogenase (LDH) release, 20.5 +/- 5.7% of the radioactivity was de...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536639
更新日期:1993-03-01 00:00:00
abstract::Microtiter plate methods were developed for the enzymatic determination of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG), and for the turbidometric determination of apolipoproteins. The micromethods resulted in accurate, precise values that were in good agreement with...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535780
更新日期:1993-02-01 00:00:00
abstract::The effect of simvastatin, a hypocholesterolemic drug, on the biosynthesis of arachidonic acid was studied in obese and lean Zucker rats. After administration of 2 mg/kg body weight/d for 13 d, delta 6 and delta 5 desaturase activities were measured in liver microsomes at two substrate concentrations. In untreated rat...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536363
更新日期:1993-01-01 00:00:00
abstract::Subcellular membranes were analyzed for their lipid composition and protein content at two developmental points representing the third instar wandering larvae and prepupal stages of Drosophila. At both stages, phosphatidylethanolamine (PE) and phosphatidylcholine (PC) were the major constituents with phosphatidylinosi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535576
更新日期:1992-12-01 00:00:00
abstract::The n-6 and n-3 fatty acid status of developing organs is the cumulative result of the diet lipid composition and many complex events of lipid metabolism. Little information is available, however, on the potential effects of the saturated fatty acid chain length (8:0-16:0) or oleic acid (18:1) content of the diet on t...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535583
更新日期:1992-12-01 00:00:00
abstract::Groups of C57Bl/6J mice, fed either a cis (C-Diet) or trans diet (T-Diet) were milked without preconditioning at 6, 8, 10 and 12 days postpartum. On day 10, groups of mice were also milked 4, 6 and 18 h after separation of the pups. Except for the 18-h separation, all T-Diet fed animals produced milk of lower fat cont...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535872
更新日期:1992-11-01 00:00:00
abstract::For four weeks, groups of eight male and eight female F344/N rats were fed diets containing 15.5, 20, 30 or 40% of energy (en%) as fat. The fat was composed of corn oil and beef tallow with 9 en% from linoleate in all diets. Females had greater mean hepatic alpha-tocopherol levels, whereas males had greater plasma alp...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535861
更新日期:1992-11-01 00:00:00
abstract::Since it was first suggested that high dietary fat is a risk factor in colon cancer, there have been several studies to test this hypothesis. Epidemiologic studies suggested a positive association between dietary fat and colon cancer. Laboratory animal model studies demonstrated that not only the amount of fat, but al...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02535855
更新日期:1992-10-01 00:00:00
abstract::The present study examined the effect of varying dietary linoleate intake (0.01, 0.24, 2.4, 24, 80 or 160 g/kg diet) for 24 weeks on the distribution of triacylglycerol (TG) molecular species in rat epididymal adipose tissue. Adipose TG fractions were purified by thin-layer chromatography and separated into different ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536030
更新日期:1992-09-01 00:00:00
abstract::The effects of 11-deoxycorticosterone and aldosterone on liver delta 5 desaturase activity were examined. Both steroid hormones significantly depressed the conversion of [1-14C] eicosatrienoic acid to arachidonic acid. However, the mechanism of action of each of these hormones was different. The effect of 11-deoxycort...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536117
更新日期:1992-08-01 00:00:00
abstract::The effects of 5c,11c,14c-eicosatrienoic acid (20:3BSO) and 5c,11c,14c,17c-eicosatetraenoic acid (20:4BSO), polyunsaturated fatty acids (PUFA) contained in Biota orientalis seed oil (BSO), on lipid metabolism in rats were compared to the effects of fats rich in linoleic acid (LA) or alpha-linolenic acid (ALA) under si...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536130
更新日期:1992-07-01 00:00:00
abstract::Trilinoleoylglycerol (LLL), trilinolenoylglycerol (LnLnLn) and four synthetic triacylglycerols were autoxidized and the volatile products were investigated to determine the effect of fatty acid glyceride position on the mechanism of hydroperoxide decomposition. Capillary gas chromatography provided a sensitive method ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536386
更新日期:1992-06-01 00:00:00
abstract::Tris(N,N-dimethyl)amide of phosphorous acid activated by addition of iodine at an optimal molar ratio of 1.05:0.05 was used as a phosphorylating reagent to synthesize cholecalciferyl-3-O-(1-2-isopropylidene-rac-glycero-3-O-)-thiophos phate and cholecalciferyl-3-O-(1,2-dipalmitoyl-rac-glycero-3-O-)thiophosphat e of met...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536388
更新日期:1992-06-01 00:00:00
abstract::Water and lipid contents, fatty acid distribution, and lipoprotein lipase activity were determined in 11 samples taken from the Omentum Majus of five dry Alpine goats. Samples were chosen to standardize sampling sites using geometric guide marks representative of different adipose tissue sites. Sample location explain...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536391
更新日期:1992-06-01 00:00:00
abstract::This study was undertaken to determine the effect of various lipid emulsions on the hepato-biliary system in rats. Rats were randomly divided into six groups and infused continuously for 48 hr with either long-chain triglycerides (LCT), medium-chain triglycerides (MCT) or a mixture of MCT and LCT. One group infused wi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536144
更新日期:1992-05-01 00:00:00
abstract::U-57,908 (RHC 80267) was shown to inhibit lipoprotein lipase (LPL) activity in cardiac myocytes from rat hearts; the concentrations required for inhibition to 50% of control activity were 1.1 microM and 2.5 microM for myocyte homogenates and a post-heparin medium preparation, respectively. The inhibition of LPL activi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536481
更新日期:1992-04-01 00:00:00
abstract::Isolated rat hepatocytes were preincubated with egg lecithin liposomes containing [3H]dolichol and [3H]dolichyl ester, and the intracellular levels and distributions of these lipids were subsequently determined after incubation in a liposome-free medium. [3H]Dolichol was recovered initially mainly in microsomes, and n...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536470
更新日期:1992-04-01 00:00:00
abstract::Adult male marmoset monkeys were fed eicosapentaenoic acid (20:5n-3) as the ethyl ester in diets containing either 32% (reference diet, no added cholesterol) or 7% (atherogenic diet with 0.2% added cholesterol) linoleic acid (18:2n-6) for 30 wk. No changes were seen in the level of phosphatidylcholine (PC) or phosphat...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536173
更新日期:1992-03-01 00:00:00
abstract::The reaction of alpha-tocopherol (alpha-T) with superoxide anion (O2-) in both dry acetonitrile and in aqueous acetonitrile solution is described. The O2- was generated by the electrochemical reduction of molecular oxygen in acetonitrile, using tetrabutylammonium bromide as an electrolyte. alpha-T was reacted with O2-...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536178
更新日期:1992-03-01 00:00:00
abstract::Existence of a dietary maximal level or threshold for incorporation of omega 3 fatty acids into membrane phospholipids is of interest as it may further define understanding of the dietary requirement for omega 3 fatty acids. To test whether feeding increasing levels of dietary omega 3 fatty acids continues to increase...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535806
更新日期:1992-02-01 00:00:00
abstract::Two unusual lipid classes were detected by thin-layer chromatography in the neutral lipids derived from goat cauda-epididymal sperm plasma membrane. The lipids were identified as wax esters and 1-O-alkyl-2,3-diacylglycerols based on chromatographic properties, identity of their hydrolysis products, and infrared/1H nuc...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537065
更新日期:1992-01-01 00:00:00
abstract::We hypothesized that tumor-bearing (TB) nude mice, because they are reported to have no detectable, circulating tumor necrosis factor (TNF)/cachectin, would regulate their plasma free fatty acid (FFA) levels normally when fasted and refed. We compared levels of individual plasma FFA in response to fasting (24 hr) and ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537055
更新日期:1992-01-01 00:00:00
abstract::The distribution of dolichol in rat liver was studied. Upon high-speed centrifugation, 9% of the total tissue dolichol was recovered in the supernatant. Dolichol was enclosed in vesicles and in lipidic particles which were isolated by gel filtration and density gradient centrifugation. The particles had a diameter of ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537050
更新日期:1992-01-01 00:00:00
abstract::In experiments on dogs, i.v. administration of platelet-activating factor (PAF) (500 ng/kg) was shown to induce hypotension which, apart from decreased myocardial contractility, was characterized by blood pooling in veins (82.6 +/- 6.8 mL/kg). This was accompanied by restriction of venous return to the heart and reduc...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536575
更新日期:1991-12-01 00:00:00
abstract::The contractions of three different regions of rat colon in response to platelet-activating factor (PAF) were compared. The ascending colon was found to be the most responsive. The slow contraction of the ascending colon induced by PAF was dependent on external Ca2+. CV-3988, a structural analog of PAF, slowly induced...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536563
更新日期:1991-12-01 00:00:00